Glutamine is an amino acid that acts as a very important nutrient for various organs and tissues, such as muscles, immune cells and also intestinal cells.
It is said to be an essential amino acid under certain conditions: in case of metabolic stress, for example, its consumption is very high by immune system cells. Therefore, in these situations, it is advisable to supplement with glutamine.
Glutamine is also interesting for the intestine because when there is metabolic stress, some organs consume glutamine in large quantities and there is a deficit in the intestine, which causes an increase in intestinal permeability.
The fundamental difference is that butyrate is a specific nutrient of the intestine, while glutamine is a nutrient of the intestine but also of many other organs and tissues.
Therefore, for glutamine to have an effect on the intestine, very large amounts are required.
On the other hand, butyrate and glutamine are more synergistic than competitors.