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FAQs – Optim Memory

What is the difference between Bacopa and Ginkgo Biloba?

Bacosides, the active ingredients of Bacopa:

– have an antioxidant action

– have an agonistic effect on the 5HT1a receptors, which are the serotonin receptors known to be involved in memory processes.

– also increase the level of acetylcholine, the neurotransmitter of memory and learning.

– increase the level of γ-aminobutyric acid (GABA) which plays an important role in adults by preventing prolonged excitation of neurons.

Bacopa helps focus (reduce distractibility), short-term memory, and improves mood.

Ginkgo Biloba contributes to increase oxygen levels in the brain. Indeed, in addition to its antioxidant activity, Ginkgo exerts a vasoregulatory activity on the whole vascular system: arteries, capillaries, veins. It is also an inhibitor of platelet aggregation and therefore not recommended with anticoagulants.

What precautions should be taken when taking Optim Memory (Bacopa/ Brahmi and Longvida Curcumin)?

 

In the absence of relevant studies on the use of turmeric (curcumin) and bacopa during pregnancy and lactation, Optim Memory is not recommended in these cases.

Bacopa has been shown, albeit inconsistently, to have a mild sedative (calming) effect, so caution should be taken when used in combination with other known sedatives.

Precautions for people on neuroleptic (phenothiazine class) and hormonal (thyroid) therapy.

Does Bacopa have any side-effects?

Bacopa has been safely used in Ayurvedic medicine for several hundred years. (Monograph Bacopa Monnieri 2004)

Bacopa with doses up to 100-200mg/day of bacosides are not associated with any known side effects (Asthana 1996)

Why combining Longvida Curcumin with Bacopa?

Longvida Curcumin has antioxidant, anti-inflammatory properties (Nahar 2014) and has neuroprotective effects as demonstrated by in-vivo and in-vitro studies (Goozee 2016).

Optim Memory’s Longvida® curcumin was developed by a group of scientists at the University of California – Los Angeles (UCLA). Clinical studies have shown that the Longvida® formulation increases the bioavailability of curcumin in its active (free) form, which is able to cross the blood-brain barrier. (Gota 2010; Koronyo 2017)

A clinical study by the University of Swinburne has shown that Longvida® curcumin (400mg/day) significantly improves working memory and reduces mental fatigue. (Cox 2014)

Bacopa acts on neurotransmitters which stimulate concentration, memory and contribute to a better mental alertness.

The combination of these two plant extracts makes it possible to act on several factors and thus play a part in improving cognitive functions.

What are the levels of bacosides in Optim Memory?

Bacognize® is HPLC standardized (10%) to bacopa glycosides, namely bacoside A3, bacopasaponin C, bacopaside II, bacopaside X, and bacopaside I. Bacognize® also contains a significant amount of flavonoids (such as luteolin and apigenin) and polyphenols which act as antioxidants.

For many bacopa extracts, analytical methodology focuses on crude estimation of ‘Total Bacosides’ or ‘Bacoside-A’ by an Ultraviolet (UV) detection method. However, this method is non-specific and may include compounds that are not active and/or not appropriate biomarkers for bacopa. The HPLC method used in the standardization of Bacognize® is highly specific and accurate.

Sources:

Asthana O. P., Srivastava J. S., Ghatak A., Gaur S. P. S., and Dhawan B. N., “Safety and tolerability of Bacosides A and B in healthy human volunteers,” Abstracts of Annual Conference of Indian Journal of Pharmacology, vol. 28, article 37, 1996.
 
Bacopa monniera. Monograph. Altern Med Rev. 2004 Mar;9(1):79-85. Review.
 
Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct 2
 
Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, Martins RN. E Br J Nutr. 2016 Feb 14;115(3):449-65
 
Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9
 
Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2017 Aug 17;2(16).
 
Nahar PP, Slitt AL, Seeram NP. Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. J Med Food. 2015 Jul;18(7):786-92