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Relieve discomfort in joints, tendons or back


Detoxify and protect against free radicals and cellular aging

What is Turmericturmeric powder & turmeric?

Turmeric also known as “golden spice turmeric” is a spice commonly used in South Asia, derived from the rhizomes of Curcuma longa L. The spice is used in traditional cuisine and medicine, and also as cosmetic and dyeing agent for clothes. Its bright yellow color comes from fat-soluble polyphenolic pigments, also known as curcuminoids. Research studies demonstrated that curcumin, the main curcuminoid representing 2% to 5% of turmeric, is likely to be the most active constituent (Begum 2008).

WHERE IS TURMERIC PRODUCED ?

India is the largest producer, consumer and exporter of turmeric in the world. Indian turmeric is considered to be the best in the world market because of its high curcumin content. India accounts for about 80% of world turmeric production and 60% of world exports.

WHAT ARE THE BENEFITS OF TURMERIC IN THE TRADITIONAL MEDICINE ?

Turmeric is used extensively in the Indian systems of medicine and is official in the Ayurvedic Pharmacopoeia of India. It has been reported to be traditionally used for digestion, joint health and to maintain normal liver functions (EMA report 2009; WHO monograph)

Highly Bioavailable Curcumin: LONGVIDA®

WHAT COUNTS IS THE ABSORPTION – NOT THE CONCENTRATION OF CURCUMIN

Curcumin, the active ingredient of turmeric, is known for its antioxidant and anti-inflammatory properties. However,

1/ Curcumin levels in dry turmeric powder are only between 2 to 5%

2/ Curcumin is very poorly absorbed into the body.

It has been demonstrated that pure curcumin is not absorbed into the blood for doses up to 8 grams per day, i.e., the equivalent of over 200 grams of turmeric powder. (Lao 2006)

 

THE SOLUTION: OPTIM CURCUMA

The formula Longvida® of Optim Curcuma has been developed by a group of scientists and physicians from the University of California – Los Angeles ( UCLA) to solve the problem of the weak absorption of curcumin into the body.

After more than 10 years of research, the key to the effectiveness of the formula Longvida® was found in the patented process: SCLP (Solid-Lipid Curcumin Particle). In this process, curcumin powder is carefully covered with natural lecithin to form small particles that increase the absorption of “free” curcumin, i.e. its active form, into the body and bring the best benefits of Turmeric with one single capsule a day.

This formulation does not contain black pepper which can be aggressive to the stomach and was recently shown that it does not to contribute to the increase absorption into the body of “free” curcumin, i.e. the biologically active form. (to learn more about curcumin absorption)

OPTIM CURCUMA: A SAFE, HIGH QUALITY AND EFFICIENT PRODUCT

The formulation of Optim Curcuma has demonstrated its efficacy in several clinical studies (read the section on studies with Longvida®).

The curcumin found in Optim Curcuma is of natural origin and is recognized as safe (GRAS). The formulation of Optim Curcuma demonstrated excellent tolerability in healthy human subjects for doses up to 4g per day or the equivalent of 10 capsules per day(Gota et al 2010).

Optim Curcuma is manufactured according to HACCP food quality principles and ISO22000 standards. The minimum curcumin content is guaranteed and controlled in Germany by the laboratory Eurofins Analytik GmbH (Latest Certificate of Analysis)

Gluten-free – Lactose-free – Does not contain any animal products, sugars, or synthetic additives such as polysorbate – GMO-Free – Suitable for vegetarians.

Optim Curcuma is registered with the Vegan Society (UK)

FAQs

HOW LONG SHOULD I TAKE OPTIM CURCUMA?

Optim Curcuma can be taken daily for at least a month and all year long. The dose or the frequency intake can then be adapted depending on the expected benefits and according to your health practitioner.

HOW MANY CAPSULES OF OPTIM CURCUMA SHOULD I TAKE A DAY?

It is recommended to take one capsule a day. If needed, you can however increase the daily intake up to two capsules a day during the first week of the cure.

IS THIS SAFE?

The patented formulation Longvida of Optim Curcuma did not show any side effects in healthy human taking up to 4 grams per day, i.e. the equivalent of 10 capsules (Gota et al 2010).

CAN TURMERIC OR CURCUMIN INTERACT, FOR INSTANCE, WITH ANTI-INFLAMMATORY DRUGS?

In 2009, the European Medicines Agency published a monograph (comprehensive study) on Turmeric (Curcuma Longa L.). This monograph does not report any interactions with other medicinal products and other forms of interactions.

ARE THERE ANY CONTRAINDICATIONS IN TAKING CURCUMIN FROM TURMERIC?

Curcumin from Turmeric o Curcuma Longa plant was reported to stimulate the gall bladder. This is the reason why, curcumin  is contraindicated in people with biliary tract obstructions. (OMS monographie). If in doubt, seek advice from your health professional.

WHAT ARE THE PRODUCTION QUALITY STANDARDS OF OPTIM CURCUMA?

Optim Curcuma is produced according to the most stringent quality control parameters, and the production process guarantees the traceability from the raw materials to the finished product (HACCP).

The formulation Longvida of Optim Curcuma is processed under good manufacturing practices (GMP) and made using all natural, high-curcumin turmeric extract perfected in India.

WHAT IS THE DIFFERENCE BETWEEN OPTIM CURCUMA AND A CURCUMA POWDER SPICE?”

A typical dry powder of curcuma found in the food store contains only between 2 to 5% curcumin.

A study performed in the universities of Michigan and San Diego (Lao 2006) shows that pure curcumin (95%) is not absorbed in the blood for doses up to 8 grams per day, i.e., the equivalent of tens of grams of turmeric powder.

This is the reason why the formulation of’Optim Curcuma has been developed to increase by at least 65 times the absorption of the active form of curcumin in the body.

DOES OPTIM CURCUMA CONTAIN BLACK PEPPER OR PIPERINE?

No

WHAT IS THE DIFFERENCE BETWEEN OPTIM CURCUMA AND CURCUMIN OR TURMERIC FORMULATIONS INCORPORATING BLACK PEPPER (PIPERINE)?

Adding black pepper to curcumin powder does not increase the absorption of the free, i.e. active, curcumin in the body.

Read more: Why adding black pepper to turmeric does not bring any benefits

However, Optim Curcuma has been developed to increase by at least 65 times the absorption of the active curcumin (free form) in the body to delivery benefits with one a capsule a day.

Longvida®: A FORMULA SUPPORTED BY SCIENTIFIC STUDIES

AN INNOVATIVE FORMULATION WITH AN OPTIMAL BIOAVAILABILITY: LONGVIDA

In the 1990s, a group of top neuroscientists at the UCLA School of Medicine, led by Dr. Sally Frautschy Ph.D. and Dr. Greg Cole Ph.D. began their quest to find a safe, effective, and affordable way to support cognitive functions.

After ten years, nearly 200 curcumin-based formulas, and endless trial and error, curcumin’s bioavailability issue has been solved, with the Optimized Curcuma’s patented Solid Lipid Curcumin Particle Technology (SLCP™).

The secret of Optim Curcuma lies in the Longvida Solid-Lipid Curcumin Particle (SLCP™) patented process which consists of encapsulating the curcumin to enhance its dissolution at a precise point in the gut and thus deliver it into both plasma and red blood cells as free curcumin, the biological active form of curcumin (DiSilvestro 2012).

BIOAVAILABILITY STUDIES IN HUMANS

Gota et al. (2010) investigated the pharmacokinetics of Longvida® preparation in adult human subjects. They performed a crossover, double-blind analysis, where six healthy men were given Longvida® SLCP curcumin preparation and 95% curcuminoids formula (containing > 60% curcumin) in capsule form in a single oral dose of 650 mg (containing 130-195 mg of curcumin from Longvida® preparation and >390 mg of curcumin from 95% curcuminoids extract). Blood samples were collected before dosing and from 1 to 12 hours after administration and plasma samples (as free form curcumin) were analyzed by HPLC. Figure 1 reports the mean free plasma curcumin concentration profile for the Longvida preparation.

Gota Graph.001
Figure 1 Mean Free Plasma Curcumin Concentration-Time Profile of healthy human subjects (N=6) from Gota et al (2010).

In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of Longvida® preparation was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected (<1 ng/ml).

Table 1 reports the maximum concentrations (Cmax) of curcumin in the plasma after dosing with either 650 mg of Longvida® preparation- minimum 130mg Curcumin – or 650 mg of a standard 95% curcuminoids extract – 390mg curcumin – (Gota et al 2010). The longvida® preparation was reported to be at least 65 times more available than standard 95% curcuminoids extracts.

 

Table 1: Curcumin Cmax of Longvida versus standard 95% Curcuminoid Extract (Gota et al. 2010)

Human Plasma Curcumin
Cmax (ng/ml)
650mg Longvida®  SLCP curcumin preparation with 130 mg curcumin min. 22.4

 

650 mg 95% Curcuminoids extract with 390mg Curcumin min.

 

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IS THE DOSAGE OF OPTIM CURCUMA EFFECTIVE ?

A recent clinical trial led by a group of researcher from the Ohio State University – USA (DiSilvestro 2012) analyzed various biological markers among healthy middle-aged people (40 to 60 years old) taking either placebo (N=19) or 400 mg of Longvida® preparation (N=19) for 30 days.

They reported that Longvida® SLCP curcumin preparation significantly reduced circulating amyloid-beta peptides, reduced vascular adhesion molecules in the blood (sICAM-1); reduced blood lipids (plasma triglycerides); reduced enzymes for physiological and emotional stress (salivary amylase); and significantly increased the antioxidant status by 24% and the endogenous antioxidant defense (catalase) by 72%; the vasodilator activity (plasma nitric oxide) by 37% and decreased liver enzymes levels (ALT: Alamine Amino Transferase) by 11%.

Chart DiSilvestro .001

   

MEMORY AND COGNITIVE FUNCTIONS

A group of researchers from the University of Swinburne in Melbourne, Australia, recently published the results of a randomised, double-blind, placebo-controlled study (Cox et al 2014).

During 4 weeks, 60 participants from 60 to 85 year old took either:

  • either 400 mg/day of either the patented LongVida SLCP curcumin complex of OptimCurcuma (80 mg curcumin)
  • or 400mg of placebo.

The authors reported that the curcumin supplementation significantly improved both acute and chronic cognitive functions, particularly working memory tasks, general fatigue, and calmness, compared with placebo.

MUSCLE RECOVERY

A study from the University of  North Texas published in Biochimica et Biophysica Acta Clinica suggests that the formulation Longvida of OptimCurcuma reduces the increases of inflammation and improved muscle recovery after a leg press exercise, compared to a placebo group. (McFarlin 2016)

28 young participants (average 20 years old) were randomly assigned to consume either 400 mg of Longvida SLCP curcumin – the formulation of OptimCurcuma – or a placebo (rice flour) for 2 days before and 4 days after the Exercise-Induced Muscle Damage. Blood samples were collected before exercise and at day 1,2,3 and 4. The muscle damage biomarker (Creatine Kinase) and the inflammatory biomarkers (cytokines: TNF-α, IL-6, IL-8, and IL-10) were measured.

Among participants in the curcumin group, researchers observed significantly smaller increases in Creatine Kinase (–48%), TNF-α (–25%), and IL-8 (–21%) following exercise compared to the placebo group. No significant decrease was found for IL-6, IL-10, or quadriceps muscle soreness.

The findings demonstrated that a daily intake of 1 capsule of the formulation of Optim Curcuma – reduced biological inflammation during recovery after the Exercise-Induced Muscle Damage (EIMD) and this may translate to faster recovery.

REFERENCES

Click to view all references

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007 Nov-Dec;4(6):807-18. http://www.ncbi.nlm.nih.gov/pubmed/17999464

Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208 http://www.ncbi.nlm.nih.gov/pubmed/18417733

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct http://www.ncbi.nlm.nih.gov/pubmed/25277322

Dadhaniya P, Patel C, Muchhara J, Bhadja N, Mathuria N, Vachhani K, Soni MG. Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies. Food Chem Toxicol. 2011 Aug;49(8):1834-42 http://www.ncbi.nlm.nih.gov/pubmed/21571027

DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79 http://www.ncbi.nlm.nih.gov/pubmed/23013352

European Patent: EP 1993365B1” Bioavailable curcuminoid formulations for treating alzheimer’s disease and other age-related disorders” http://www.google.com/patents/EP1993365A2?cl=en

Frautschy, SF “Improving bioavailability of curcumin by solid lipid particle for treatment of Alzheimer’s (AD)” at the 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008
Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9 http://www.ncbi.nlm.nih.gov/pubmed/20092313

Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53 http://www.ncbi.nlm.nih.gov/pubmed/19594223

McFarlin B.K., A.S. Venable, A.L. Henning, J.N Best Sampson, K. Pennel, J.L. Vingren, D.W. Hill; Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin;

BBA Clinical, Volume 5, June 2016, Pages 72–78.
Nahar PP, Slitt AL, Seeram NP. Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. J Med Food. 2014 Dec 9 – http://www.ncbi.nlm.nih.gov/pubmed/25490740

Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 2013 Feb;75(2):450-62 http://www.ncbi.nlm.nih.gov/pubmed/22725836

WHO Monographs on Selected Medicinal Plants – Volume 1; http://apps.who.int/medicinedocs/en/d/Js2200e/14.html#Js2200e.14