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Bacopa Monnieri and curcumin

play a part in improving concentration, attention, and memory

help to both maintain a clear mind and improve mental energy

Food supplement based on Bacopa monnieri (Bacognize®) and optimised curcumin Longvida®

BACOPA MONNIERI (L.) PENNEL OR BRAHMI

BENEFITS

Bacopa and curcumin contribute to improving cognitive abilities:

  • play a part in improving concentration, attention, and memory
  • help to both maintain a clear mind and improve mental energy

WHAT IS THE MECHANISM OF ACTION OF BACOPA?

Bacosides, the active ingredients of Bacopa, act positively on neurotransmitters. In particular, they are increasing:

– the serotonin level that is involved in memory processes.
– the level of acetylcholine, the neurotransmitter of memory and learning
– and the level of γ-aminobutyric acid (GABA) which plays an important role in adults by preventing prolonged excitation of neurons. (Charles 2011; Rajan 2011)

CLINICAL STUDIES WITH BACOGNIZE®

The extract of Bacopa Monnieri, Bacognize®, used in the formulation of Optim Memory was validated by two clinical trials conducted with volunteer students and people over 50 years of age. (Goswami 2011; Kumar 2016).

A study in people over 50 years old (Goswami 2011)

For 6 months, 39 people with early Alzheimer’s (average age 65 years) took 300 mg of Bacognize® twice daily.

Significant results:
– Improved spatial and temporal orientation
– Improved attention
– Improved mood and decreased irritability and insomnia

Study with students (Kumar 2016)

For 6 weeks, 42 students took 2 times daily either 150 mg of Bacognize® or a placebo.

Significant results (Bacognize® Group):
– Improved concentration and attention
– Improvement of immediate memory and working memory
– Better linguistic understanding

Effects of taking Bacopa Monnieri (Bacognize®) on the score of the Mini-Mental State Examination Scale (MMSES) – Goswami 2011

Other studies: Children with attention deficit disorder (ADHD)

Over a 16-week period, a double-blind, randomized, placebo-controlled trial was conducted with 36 children diagnosed with ADHD (mean age 8-9 years).

19 children received every 12 hours and for 12 weeks 50 mg of Bacopa alcohol extract, followed by 4 weeks of placebo. The remaining 17 children received a placebo for 16 weeks.

Both groups were evaluated at baseline and at 4, 8, 12 and 16 weeks, and improvements were observed in the Bacopa group, particularly in sentence repetition, logical memory and learning tasks, which were maintained 4 weeks after discontinuation. (Negi 2000)

LONGVIDA® CURCUMIN

MEMORY AND COGNITIVE FUNCTIONS

A group of researchers from the University of Swinburne in Melbourne, Australia, recently published the results of a randomised, double-blind, placebo-controlled study (Cox et al 2014).

During 4 weeks, 60 participants from 60 to 85 year old took either:

  • either 400 mg/day of either the patented LongVida SLCP curcumin complex of OptimCurcuma (80 mg curcumin)
  • or 400mg of placebo.

The authors reported that the curcumin supplementation significantly improved both acute and chronic cognitive functions, particularly working memory tasks, general fatigue, and calmness, compared with placebo.

Longvida® curcumin crosses the blood-brain barrier

A team of researchers from Cedars-Sinai Medical Center in Los Angeles (United States) has demonstrated that Longvida® curcumin, Optim Curcuma’s formula, crosses the blood-brain barrier with its solid-lipid microencapsulation process that increases the bioassimilation and efficacy of curcumin in its active form by 65 times (Koronyo 2017).

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FAQs

WHAT IS THE DIFFERENCE BETWEEN BACOPA AND GINKGO BILOBA?

Bacosides, the active ingredients of Bacopa:

– have an antioxidant action

– have an agonistic effect on the 5HT1a receptors, which are the serotonin receptors known to be involved in memory processes.

– also increase the level of acetylcholine, the neurotransmitter of memory and learning.

– increase the level of γ-aminobutyric acid (GABA) which plays an important role in adults by preventing prolonged excitation of neurons.

Bacopa helps focus (reduce distractibility), short-term memory, and improves mood.

Ginkgo Biloba contributes to increase oxygen levels in the brain. Indeed, in addition to its antioxidant activity, Ginkgo exerts a vasoregulatory activity on the whole vascular system: arteries, capillaries, veins. It is also an inhibitor of platelet aggregation and therefore not recommended with anticoagulants.

WHAT PRECAUTIONS SHOULD BE TAKEN WHEN TAKING OPTIM MEMORY (BACOPA/ BRAHMI AND LONGVIDA CURCUMIN)?

In the absence of relevant studies on the use of turmeric (curcumin) and bacopa during pregnancy and lactation, Optim Memory is not recommended in these cases.

Bacopa has been shown, albeit inconsistently, to have a mild sedative (calming) effect, so caution should be taken when used in combination with other known sedatives.

Precautions for people on neuroleptic (phenothiazine class) and hormonal (thyroid) therapy.

DOES BACOPA HAVE ANY SIDE-EFFECTS?

Bacopa has been safely used in Ayurvedic medicine for several hundred years. (Monograph Bacopa Monnieri 2004)

Bacopa with doses up to 100-200mg/day of bacosides are not associated with any known side effects (Asthana 1996)

WHY COMBINING LONGVIDA CURCUMIN WITH BACOPA?

Longvida Curcumin has antioxidant, anti-inflammatory properties (Nahar 2014) and has neuroprotective effectsas demonstrated by in-vivo and in-vitro studies (Goozee 2016).

Optim Memory’s Longvida® curcumin was developed by a group of scientists at the University of California – Los Angeles (UCLA). Clinical studies have shown that the Longvida® formulation increases the bioavailability of curcumin in its active (free) form, which is able to cross the blood-brain barrier. (Gota 2010; Koronyo 2017)

A clinical study by the University of Swinburne has shown that Longvida® curcumin (400mg/day) significantlyimproves working memory and reduces mental fatigue. (Cox 2014)

Bacopa acts on neurotransmitters which stimulate concentration, memory and contribute to a better mental alertness.

The combination of these two plant extracts makes it possible to act on several factors and thus play a part in improving cognitive functions.

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References

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Asthana O. P., Srivastava J. S., Ghatak A., Gaur S. P. S., and Dhawan B. N., “Safety and tolerability of Bacosides A and B in healthy human volunteers,” Abstracts of Annual Conference of Indian Journal of Pharmacology, vol. 28, article 37, 1996.

Bacopa monniera. Monograph. Altern Med Rev. 2004 Mar;9(1):79-85. Review. 

Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum, and hippocampus. Phytother Res 2000;14:174-179.

Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera in an experimental study. Phytomedicine 1998;5:77-82.

Charles PD, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. J Ethnopharmacol. 2011 Mar 8;134(1):55-61.

Chowdhuri DK1, Parmar D, Kakkar P, Shukla R, Seth PK, Srimal RC. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res  2002;16:639-645.

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct 2

Deepak M, Sangli GK, Arun PC, Amit A. Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. Phytochem Anal. 2005 Jan-Feb;16(1):24-9.

Enz A, Amstutz R, Boddeke H, et al. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer’s disease. Prog Brain Res  1993;98:431-438.

Gohil KJ, Patel JA. A review on Bacopa monniera: Current research and future prospects . International Journal of Green Pharmacy. Jan-March 2010 1-9

Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, Martins RN. E Br J Nutr. 2016 Feb 14;115(3):449-65

Goswami S, Saoji A, Kuman N, Thawani V, Tiwari M, Thawani M. Effect of Bacopa monnieri on cognitive functions in Alzheimer’s disease patients. International Journal of Collaborative Research on Internal Medicine & Public Health. 2011;3(3):179.

Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9

Gurib-Fakim A, Brendler T. Medicinal and Aromatic Plants of Indian Ocean Islands. Stuttgart: Medpharm Scientific Publishers; 2004.

Kapoor L, ed. CRC Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press; 1990.

Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 2002;81:281-285.

Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2017 Aug 17;2(16).

Kumar N, Abichandani LG, Vijay Thawani, Gharpure KJ, Naidu MUR, Venkat Ramana G.  Efficacy of Standardized Extract of Bacopa monnieri (Bacognize) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine Volume 2016, 1-8.

Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Alt Comp Med. 2010;16(7):753.759.

Nahar PP, Slitt AL, Seeram NP. Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. J Med Food. 2015 Jul;18(7):786-92

Negi KS, Singh YD, Kushwaha KP, et al. Clinical evaluation of memory enhancing properties of Memory Plus in children with attention deficit hyperactivity  disorder. Ind J Psychiatry 2000;42:Supplement

Parrotta J. Healing Plants of Peninsular India. New York: CABI Publishing; 2001.

Rajan KE, Singh HK, Parkavi A, Charles PD. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). Neurochem Res. 2011 Nov;36(11):2136-44. 

Russo A, Borrelli F, Campisi A, et al. Nitric oxide related toxicity in cultured astrocytes: effect of Bacopa monniera. Life Sci  2003;73:1517-1526.

Russo A, Izzo A, Borrelli F, et al. Free radical scavenging capacity and protective effect of Bacopa monniera  L. on DNA damage. Phytotherapy Res  2003;17:870-875.

Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera  Linn. (Brahmi). Indian J Pharmacol  1997;29:S359-S365.

Singh RH, Singh L. Studies on the anti-anxiety effect of the Medyha Rasayana drug, Brahmi (Bacopa monniera Wettst.) – Part 1. J Res Ayur Siddha 1980;1:133-148.

Vohora D, Pal SN, Pillai KK. Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. J Ethnopharmacol 2000;71:383-390.

Zhou Y, Shen YH, Zhang C, Su J, Liu RH, Zhang WD. Triterpene saponins from Bacopa monnieri and their antidepressant effect in two mice models. J Nat Prod. April 2007;70(4):652-655

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