Bacopa and curcumin contribute to improve cognitive abilities:
Bacosides, the active ingredients of Bacopa, act positively on neurotransmitters. In particular, they increase:
– the serotonin level that is involved in memory processes.
– the level of acetylcholine, the neurotransmitter of memory and learning
– and the level of γ-aminobutyric acid (GABA) which plays an important role in adults by preventing prolonged excitation of neurons. (Charles 2011; Rajan 2011)
The extract of Bacopa Monnieri, Bacognize®, used in the formulation of Optim Memory was validated by two clinical trials conducted with volunteer students and people over 50 years of age. (Goswami 2011; Kumar 2016).
For 6 months, 39 people with early Alzheimer’s (average age 65 years) took 300 mg of Bacognize® twice daily.
– Improved spatial and temporal orientation
– Improved attention
– Improved mood and decreased irritability and insomnia
For 6 weeks, 42 students took 2 times daily either 150 mg of Bacognize® or a placebo.
Significant results (Bacognize® Group):
– Improved concentration and attention
– Improvement of immediate memory and working memory
– Better linguistic understanding
Effects of taking Bacopa Monnieri (Bacognize®) on the score of the Mini-Mental State Examination Scale (MMSES) – Goswami 2011
Over a 16-week period, a double-blind, randomized, placebo-controlled trial was conducted with 36 children diagnosed with ADHD (mean age 8-9 years).
19 children received every 12 hours and for 12 weeks 50 mg of Bacopa alcohol extract, followed by 4 weeks of placebo. The remaining 17 children received a placebo for 16 weeks.
Both groups were evaluated at baseline and at 4, 8, 12 and 16 weeks, and improvements were observed in the Bacopa group, particularly in sentence repetition, logical memory and learning tasks, which were maintained 4 weeks after discontinuation. (Negi 2000)
A group of researchers from the University of Swinburne in Melbourne, Australia, recently published the results of a randomised, double-blind, placebo-controlled study (Cox et al 2014).
During 4 weeks, 60 participants from 60 to 85 year old took either:
The authors reported that the curcumin supplementation significantly improved both acute and chronic cognitive functions, particularly working memory tasks, general fatigue, and calmness, compared with placebo.
A team of researchers from Cedars-Sinai Medical Center in Los Angeles (United States) has demonstrated that Longvida® curcumin, Optim Curcuma’s formula, crosses the blood-brain barrier with its solid-lipid microencapsulation process that increases the bioassimilation and efficacy of curcumin in its active form by 65 times (Koronyo 2017).
Bacosides, the active ingredients of Bacopa:
– have an antioxidant action
– have an agonistic effect on the 5HT1a receptors, which are the serotonin receptors known to be involved in memory processes.
– also increase the level of acetylcholine, the neurotransmitter of memory and learning.
– increase the level of γ-aminobutyric acid (GABA) which plays an important role in adults by preventing prolonged excitation of neurons.
Bacopa helps focus (reduce distractibility), short-term memory, and improves mood.
Ginkgo Biloba contributes to increase oxygen levels in the brain. Indeed, in addition to its antioxidant activity, Ginkgo exerts a vasoregulatory activity on the whole vascular system: arteries, capillaries, veins. It is also an inhibitor of platelet aggregation and therefore not recommended with anticoagulants.
In the absence of relevant studies on the use of turmeric (curcumin) and bacopa during pregnancy and lactation, Optim Memory is not recommended in these cases.
Bacopa has been shown, albeit inconsistently, to have a mild sedative (calming) effect, so caution should be taken when used in combination with other known sedatives.
Precautions for people on neuroleptic (phenothiazine class) and hormonal (thyroid) therapy.
Bacopa has been safely used in Ayurvedic medicine for several hundred years. (Monograph Bacopa Monnieri 2004)
Bacopa with doses up to 100-200mg/day of bacosides are not associated with any known side effects (Asthana 1996)
Longvida Curcumin has antioxidant, anti-inflammatory properties (Nahar 2014) and has neuroprotective effectsas demonstrated by in-vivo and in-vitro studies (Goozee 2016).
Optim Memory’s Longvida® curcumin was developed by a group of scientists at the University of California – Los Angeles (UCLA). Clinical studies have shown that the Longvida® formulation increases the bioavailability of curcumin in its active (free) form, which is able to cross the blood-brain barrier. (Gota 2010; Koronyo 2017)
A clinical study by the University of Swinburne has shown that Longvida® curcumin (400mg/day) significantlyimproves working memory and reduces mental fatigue. (Cox 2014)
Bacopa acts on neurotransmitters which stimulate concentration, memory and contribute to a better mental alertness.
The combination of these two plant extracts makes it possible to act on several factors and thus play a part in improving cognitive functions.
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