Alzheimer’s disease is a chronic neurodegenerative disease that usually starts slowly, worsens over time and generally appears after 65 years. The disease process is associated with oxidative stress, neuroinflammation, and damage of the nervous tissues. Two types of lesions of the nervous tissue characterize Alzheimer’s disease: accumulation of senile plaques (or beta-amyloid deposits, Aβ) and formation of tangles through tau proteins (p-tau) in the brain. The main component of these Aβ plaques is the beta-amyloid peptide containing 42 amino acids (Aβ42). This peptide has been shown to induce neuronal death.

Dr. Maiti and Dr. Dubar from the Central Michigan University (USA) have recently published the results of an in vitro study demonstrating the neuroprotective effects of Longvida free curcumin.

This in vitro study was designed to compare the neuroprotective effects of a dietary non-formulated curcumin (80% curcumin extract) and/or Longvida Free Curcumin after exposing mouse neuroblastoma to the A?42 peptide for 24 hours.

Longvida outperformed the unformulated curcumin in all tested parameters. Longvida showed greater permeability than non-formulated curcumin. This is explained by the lipidic membrane of Longvida containing both lecithin and stearic acid (Solid Lipid Curcumin Particles).

Longvida free curcumin decreased the production of reactive oxygen species (ROS) production, p-tau protein and improved cell survival by preventing apoptotic death.

The formula Longvida has been developed by a group of scientists and physicians from the University of California – Los Angeles ( UCLA) to solve the problem of the weak absorption of curcumin into the body.

After more than 10 years of research, the key to the effectiveness of Longvida, the formula of Optim Curcuma, was found in the SLCP patented process (Solid-Lipid Curcumin Particle). In this process, curcumin powder is carefully covered with natural lecithin and stearic acid to form small particles that increase the absorption of “free” curcumin, i.e. its active form, into the body, allowing it to survive digestion and enter the bloodstream, target tissues, and cross the blood-brain barrier.

It is thus important to maintain the curcumin in its free form to get the most of the benefits of curcumin.

Références:

Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.
Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9.
Maiti P, Dunbar GL. Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42. Int J Alzheimers Dis. 2017;2017:4164872.

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